Intracellular signal transduction of CD83 in DC

Immune Modulation

Head of Department:
Prof. Dr. rer. nat. Alexander Steinkasserer (PhD)

Intracellular signal transduction of CD83 in DC

Project manager: Prof. Dr. A. Steinkasserer

The main research focus of the project concentrates on structural- and signal transduction pathway analyses of the membrane bound CD83 molecule. Specific binding domains/-partners have been identified using a yeats two hybrid screen. Site directed mutagenesis-, transfection-, immune-precipitation-, and co-immunofluorescence-studies have been used to further characterize the protein-protein interaction, the N-linked glycosylation, and the activation of mCD83 on a molecular level. To identify possible binding motifs in silico, a bioinformatic modeling study has been performed. The elucidation of the mCD83 signaling pathway in mature human DC will open new and specific therapeutic targets.

Publications

 
Contact
Prof. Dr. rer. nat. Alexander Steinkasserer PhD
phone: +49 9131 85-36725
fax: +49 9131 85-35799
e-mail: alexander.steinkasserer@uk-erlangen.de
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